Pengamatan Sero-Virologi Beberapa Jenis Antigen Virus pada Serum Talipusat Bayi di RS. Cipto Mangunkusumo, JakartaDjokoYuwonoauthorPerinatal infection due to viral agents from mother to neonate is still a major cause of viral transmission in developing countries. Several type of viruses which are known to be transmitted vertically or perinatally from mother to neonates are : Hepatitis B virus, Herpes simplex, Rubella and Cytomegalovirus. In attempt to estimate the real problem of viral diseases which are vertically or perinatally transmissible among infants, a survey on sero - virology of several type viral antigens among neonates who were borned in Dr. Cipto Mangunkusumo hospital, was carried out. A total of 227 blood samples of umbillical cord were examined for the presence of their viral antigens such as : Hepatitis B surface antigens (HBsAg), Herpers simplex type 1 and 2, and anti-rubella IgM as an indicator of early infection due to rubella virus in the fetus. The detection of antigens and anti-rubella IgM in the serum were done by ELISA methode using reagents which are commercially available. The result of the study indicated that there was a possibility of perinatal infection due to related viruses, i.e.: 2.2% ; 1.9% and 14.3% due to HBsAg; Herpes simplex type 1 and type 2 respectivelly, however none of the serum indicated seropositive IgM against rubella virus infection.WQ 200-212 Reproduction. Pregnancy1987Badan Penelitian dan Pengembangan KesehatanArticle