?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F1787%2F&rft.title=Pengaruh+Penambahan+Asam+Folat%2C+Vitamin+B12+dan+B6+pada+Pil+Besi+terhadap+Kadar+Homocystein+Plasma+Ibu+Hamil+Anemia&rft.creator=Rustan%2C+Effendi&rft.subject=WQ+200-212+Reproduction.+Pregnancy&rft.description=Background%3A+In+the+last+decade%2C+it+has+been+known+that+a+metabolic+effect+of+folate+deficiency+is+an+elevation+of+total+plasma+homocysteine.+Elevated+plasma+homocysteine+(tHcy)+concentrations+are+associated+with+the+neural+tube+defects+in+the+foetus+in+pregnant+women.+Recent+studies+have+shown+that+the+plasma+homocysteine+can+be+lowered+by+supplementation+of+folic+acid+in+amount+1-2+times+the+recommended+dietary+allowance.+Preliminary+evidence+indicated+that+vitamin+B12+and+vitamin+B6+may+be+beneficial+when+included+folic+acid+supplementation.++++++Objective%3A+To+compare+the+homocysteine+lowering+potential+of+folic+acid+supplementation+containing+different+doses+of+folic+acid%2C+vitamin+B12+and+B6.++++++Method%3A+Randomised+clinical+trial+with+double+blinded+placebo+controlled+study.+The+study+was+conducted+at+six+villages+in+the+area+of+four+Public+Health+Centre+in+Bogor+district.+Anaemic+pregnant+women+in+their+12-20th+week+of+pregnancy+(n%3D74)+divided+into+two+groups+and+received+a+treatment+for+14+week.+The+control+group+(n+%3D+36)+received+capsulated+iron+pill+containing+200+mg+ferrous+sulfate+%2B+250+ug+folic+acid%2C+which+is+equivalent+with+iron+pill's+using+in+anaemia+control+program.+While+the+treatment+group+(n+%3D+38)+received+200+mg+ferrous+sulfate+%2B+500+ug+folic+acid+%2B+250+ug+vitamin+B12+%2B+5+mg+vitamin+B6.+Before+and+after+intervention+data+on+haemoglobin%2C+haematocrite%2C+and+plasma+homocysteine+were+obtained+from+all+subjects.++++++Results%3A+At+the+beginning+of+the+study+98%2C65+%25+of+the+pregnant+women+had+mild+anaemia+(Hb+9.0-10.9+g+%25)+and+1.35+%25+with+moderate+anaemia+(Hb+7.0-8.9+g%25).+Plasma+homocysteine+were+normohomocysteinemic+with+concentrations+ranging+from+3.0+to+10.9+u+mol%2FL%3B+median+value+of+the+two+groups+was+6.65+umol%2FL.+There+was+no+significant+reductions+or+significant+differences+(p+%3E+0.05)+in+plasma+homocysteine+were+observed+in+the+two+groups+receiving+vitamin+supplementation.++++++Conclusions%3A+These+results+suggested+that+there+was+no+different+effect+due+to+the+different+dosage+of+folic+acid+supplement's+to+plasma+homocysteine+concentrations%2C+suggesting+that+250+ug+folic+acid+a+day+may+be+an+optimal+homocysteine+lowering+dose%2C+and+the+addition+of+vitamin+B12+and+vitamin+B6+supplementation+were+not+necessary.&rft.publisher=Center+for+Research+and+Development+of+Nutrition+and+Food%2C+NIHRD&rft.date=2001&rft.type=Monograph&rft.type=NonPeerReviewed&rft.identifier=++Rustan%2C+Effendi++(2001)+Pengaruh+Penambahan+Asam+Folat%2C+Vitamin+B12+dan+B6+pada+Pil+Besi+terhadap+Kadar+Homocystein+Plasma+Ibu+Hamil+Anemia.++Project+Report.+Center+for+Research+and+Development+of+Nutrition+and+Food%2C+NIHRD.+++++