Repositori BKPKHasil Guna Kaplet Bawang Putih Dibanding Fenofibrat pada Penderita HiperlipidemiYun AstutiNugrohoauthorBawang Putih (Allium sativum L) dikenal masyarakat sebagai obat penurun kadar kolesterol. Di pasaran (produk jadi) banyak beredar sediaan yang mengandung Bawang Putih antara lain Kaplet Bawang Putih. Oleh karena itu telah dilakukan penelitian ?Hasil Guna Kaplet Bawang Putih Dibanding Fenofibrat pada Penderita Hiperlipidemi?. Rancangan penelitian RCTs, penempatan subyek penelitian dilakukan secara random terhadap 81 penderita hiperlipidemi (42 kelompok kaplet Bawang Putih dan 39 kelompok Fenofibrat) untuk membandingkan efek kaplet Bawang Putih dosis 400 mg/hr dan Fenofibrat dosis 200 mg/hr dalam menurunkan kadar lipid darah. Hasil penelitian, setelah pemberian obat selama 5 minggu, penurunan kadar kolesterol total kelompok kaplet Bawang Putih 40,35 +/- 18,44 mg/dl dan kelompok Fenofibrat 51,36 +/- 25,37 mg/dl (p=0,027). Penurunan kadar terigliserida kelompok kaplet Bawang Putih 9,61 +/- 61,07 mg/dl dan kelompok Fenofibrat 34,27 +/- 59,96 mg/dl (p=0,071), LDL-kolesterol kelompok kaplet Bawang Putih 38,69 +/- 24,12 dan kelompok Fenofibrat 47,97 +/- 31,63 mg/dl (p=0,140). Tidak ada perubahan yang berarti pada LDL-kolesterol. Pemberian kaplet Bawang Putih selama 5 mingu tidak mempengaruhi kadar GPT,GOT, Ureum dan Kreatinin. Kesimpulan, pemberian kaplet Bawang Putih dosis 400 mg/hr selama 5 minggu berhasil guna dalam menurunkan kadar lipid darah.WD 200-226 Metabolic Diseases2003Pusat Penelitian dan Pengembangan Farmasi dan Obat TradisionalMonograph

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