?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F2501%2F&rft.title=CLINICAL+TRIAL+OF+THE+HEAT-STABLE+BCG+VACCINE+1993%2F1994&rft.creator=Prijanto%2C+Muljati&rft.creator=Musa%2C+Dahlan+Ali&rft.creator=Gunawan%2C+Suriadi&rft.subject=WF+140-900+Diseases+of+the+Respiratory+System&rft.description=Cold+chain+system+is+still+a+big+problem+in+the+Expanded+Programme+on+Immunization+in+several+developing+countries+especially+in+tropical+areas.+For+this+reason+heat-stable+BCG+vaccines+have+been+developed+in+Japan+since+1987.+++++++A+field+trial+of+heat-stable+BCG+vaccine+was+conducted+in+Indonesia+in+1993-1994.+In+this+field+produced+heat-stable+BCG+vaccine+was+compared+with+ordinary+BCG+vaccine+produced+in+Japan+and+BCG+vaccine+used+in+EPI+in+Indonesia+made+from+Paris+1173-P2+strain+produced+by+Bio+Farma%2C+Bandung%2C+Indonesia.+++++++The+objective+of+this+study+is+to+know+the+immune+response+and+safety+of+the+heat-stable+BCG+vaccine+(after+3+months+storage+at+40%C3%82%C2%B0C)+in+comparison+with+the+ordinary+Japanese+dried+BCG+vaccine+and+the+BCG+vaccine+used+for+EPI+in+Indonesia.+The+immune+response+is+indicated+by+the+tuberculin+test+with+the+mean+diameter+of+the+post-vaccinal+allergic+reaction.+++++++The+safety+of+the+vaccine+is+characterised+by+the+local+reaction+on+the+site+of+inoculation%2C+reaction+on+regional+lymph+node+and+the+development+of+complications+caused+by+BCG+vaccination.+++++++The+study+was+carried+out+in+4+Health+Centres+in+Jakarta+.+The+health+centers+are+Cempaka+Putih%2C+Johar+Baru+located+in+Central+Jakarta+and+Matraman%2C+Pulo+Gadung+located+in+East+Jakarta.+There+were+440+infants+included+in+this+study.+In+this+study+no+side+reaction+of+immunization+were+found+on+examinination.+++++++The+mean+diameter+of+tuberculin+reaction+in+the+groups+receiving+heat-stable+BCG%2C+BCG+Japan+and+BCG+Indonesia+were+9.75+mm%2C+10.25+mm+and+7.43+mm%2C+respectively.+++++++The+tuberculin+conversion+rates+in+the+groups+of+heat-stable+BCG+vaccine%2C+ordinary+BCG+vaccine+and+Bio+Farma+vaccine+are+85.70%25%2C+89.90%25+and+70.00%25%2C+respectively.+++++++Conclusions+of+this+study+are+The+heat-stable+BCG+vaccine+produced+by+Japan+BCG+Laboratory+gives+no+significant+differences+in+tuberculin+conversion-rates%2C+tuberculin+reaction+and+scar+formation+when+compared+with+ordinary+Japanese+BCG+vaccine+and+Indonesian+BCG+vaccine.+++++++-+All+three+Vaccines+used+in+this+study+are+safe.++++++-+The+heat-stable+BCG+vaccine+can+be+kept+at+40%C3%82%C2%B0C+for+at+least+3+months.&rft.publisher=Pusat+Penelititan+dan+Pengembangan+Pemberantasan+Penyakit&rft.date=1994&rft.type=Monograph&rft.type=NonPeerReviewed&rft.identifier=++Prijanto%2C+Muljati+and+Musa%2C+Dahlan+Ali+and+Gunawan%2C+Suriadi++(1994)+CLINICAL+TRIAL+OF+THE+HEAT-STABLE+BCG+VACCINE+1993%2F1994.++Project+Report.+Pusat+Penelititan+dan+Pengembangan+Pemberantasan+Penyakit.+++++