?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F2534%2F&rft.title=TREATMENT+OF+SYMPTOMATIC+VIVAX+MALARIA+IN+BANGKA&rft.subject=WC+680-950+Tropical+and+Parasitic+Diseases&rft.description=Background%3A+Amodiaquine+(AQ)+showed+very+effective+for+treatment+of+symptomatic+vivax+malaria+in+Bangka.+The+combination+of+artesunate+(ATS)+and+AQ+was+effective+for+treatment+of+uncomplicated+falciparum+malaria+in+Africa.+This+combination+is+a+potential+combination+for+both+treatments+of+uncomplicated+falciparum+and+vivax+malaria+in+Indonesia.+Combination+of+artemisinin+(ART)+and+piperaquine+(PPQ)+is+promising+for+future+use+because+it+is+highly+effective+and+safe%2C+simple%2C+and+relatively+cheap.+We+therefore+canied+out+this+trial+to+provide+evidence+whether+the+therapeutic+efficacies+of+a+%3AHfay+single+daily+dose+regimen+of+combined+ATS+and+AQ+(ATS3%2BAQ3)+were+similar+to+a+2-day+single+daily+dose+regimen+of+ART+and+PPQ+(ART2%2BPPQ2+)in+both+falciparum+and+vivax+malaria.++++++Patients+and+methods%3A+This+trial+was+a+prospective+evaluation+and+a+comparative+study+of+the+therapeutic+efficacy+of+3-day+single+daily+dose+regimen+of+combined+ATS+(4+mg%2Fkg+bw%2Fdose)+and+AQ+(25+mg+base%2Fkg+bw+in+3+days)%2C+and+a+2-day+single+daily+dose+of+ART+(2.5+mglkg+bw%2Fdose)+and+++++PPQ+(15+mg%2Fkg+bw%2Fdose)+in+uncomplicated+falciparum+and+vivax+malaria+patients+based+on+the+new+version+of+2003+WHO+protocol.+The+trial+enrolled+each+arm+88+cases+with+a+total+of+176+uncomplicated+falciparum+malaria+and+176+vivax+malaria+assuming+proportion+of+treatment+failures+of+both+regimens+were+similar+to+5%25+within+confidence+level+of+95%25+and+the+precision+of+5%25.+Patients+were+randomized%2C+stratified+by+age+(children+and+adults)%2C+and+observed+for+28+days.+The+primary+endpoint+was+Adequate+Clinical+and+Parasitological+Response+(ACPR)+corrected+by+PCR.+Analysis+was+by+evaluability+and+intention+to+treat+analysis.++++++Findings%3A+The+therapeutic+efficacies+of+ATS3%2BAQ3+and+ART2%2BPPQ2+were+not+different+and+effective+for+treatment+of+falciparum+malaria+and+vivax+malaria.+Both+regimens+had+high+ACPR+of+%3E90%25%2C+means+of+Fever+Clearance+Time+and+Parasite+Clearance+Time+of+%3C1.5+days%2C+hemoglobin+recovery+of+%3E95%25%2C+persistent+gametocyte+caniage+in+falciparum+malaria+patients+over+day+7%2C+and+common+adverse+reactions+were+nausea+and+vomiting+to+ATS3%2BAQ3+and+ART2%2BPPQ2.++++++Interpretation%3A+ATS3%2BAQ3+and+ART2%2BPPQ2+were+safe%2C+tolerated%2C+and+efficacious+for+the+treatment+of+falciparum+malaria+and+vivax+malaria.+Primaquine+should+be+given+for+radical+cure+as+earlier+as+possible.+Cost+remains+a+problem+for+malaria+control.&rft.publisher=Pusat+Penelitian+dan+Pengembangan+Pemberantasan+Penyakit&rft.date=2005&rft.type=Monograph&rft.type=NonPeerReviewed&rft.identifier=++UNSPECIFIED++(2005)+TREATMENT+OF+SYMPTOMATIC+VIVAX+MALARIA+IN+BANGKA.++Project+Report.+Pusat+Penelitian+dan+Pengembangan+Pemberantasan+Penyakit.+++++