?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F2585%2F&rft.title=THE+CLINICAL+TRIAL+OF+DPT+HEAT-STABLE+VACCINE&rft.creator=Prijanto%2C+Muljati&rft.creator=Musa%2C+Dahlan+Ali&rft.creator=Simanjuntak%2C+Cyrus+H.&rft.creator=Handayani%2C+Sarwo&rft.subject=WC+195-425+Infection.+Bacterial+Infections&rft.description=DTP+acelluler+vaccine+freeze+dried+has+been+developed+by+Kaketsuken%2C+Japan+to+solve+the+cold+chain+problems+especially+in+tropical+countries.+The+pertussis+acelluler+vaccine+contain+2+mcg+PN+of+Pertussis+toxin+(PT)+and+8+mcg+PN+of+FHA+(filamentous+haemagglutinin)+per+mililiter.+The+aim+of+this+study+is+to+know+the+immunogenicity+and+adversed+reaction+of+DTaP+heat-stable+vaccine+(treated+40%C3%82%C2%B0C+for+3+months)%2C+compared+with+2+kinds+of+liquid+DTP+vaccine+(whole+cell+and+acelluler+pertussis+vaccine)+and+freeze+-dried+DTaP+vaccine+not+treated+at+40%C3%82%C2%B0C.+Subject+of+the+study+are+1625+infants+of+2-3+months+of+age+selected+randomly+and+devided+into+4+groups.+Group+A+consist+of+500+healthy+infants+immunized+with+DTaP+heat-stable+(HS).+Group+B%2C+C%2C+and+D+each+consist+of+375+healthy+infants+immunized+with+DTwP%2C+DTaP+liquid+and+DTaP+not+treated%2C+respectively.+Side+reactions+were+monitored+for+7+days%2C+twice+of+the+first+day+and+once+a+day+for+the+rest.+A+hundred+sera+were+collected+from+each+groups+examined+for+diphtheria%2C+tetanus+and+pertussis+antibody.+Diphtheria+and+tetanus+antibody+were+measured+by+neutralization+test+using+vero+well+and+Passive+haemaglutination+test+(PHA).+Anti+PT+and+anti+FHA+antibody+of+pertussis+were+measured+by+ELISA.+The+local+and+sistemic+reactions+in+infants+post+vaccination+with+3+different+DTaP+vaccines+were+not+significantly+different+observed+within+2+and+7+days+of+each+injection+of+each+vaccine.+There+was+significant+different+of+side+reaction+between+infants+immunized+with+DTwP+comparing+with+3+groups+of+infants+received+DTaP+vaccine+(p%3C0.005).+There+was+no+severe+reactions+observed+during+this+trial.&rft.publisher=Pusat+Penelitian+dan+Pengembangan+Penyakit+Menular&rft.date=1995&rft.type=Monograph&rft.type=NonPeerReviewed&rft.identifier=++Prijanto%2C+Muljati+and+Musa%2C+Dahlan+Ali+and+Simanjuntak%2C+Cyrus+H.+and+Handayani%2C+Sarwo++(1995)+THE+CLINICAL+TRIAL+OF+DPT+HEAT-STABLE+VACCINE.++Project+Report.+Pusat+Penelitian+dan+Pengembangan+Penyakit+Menular.+++++