<mets:mets OBJID="eprint_2926" LABEL="Eprints Item" xsi:schemaLocation="http://www.loc.gov/METS/ http://www.loc.gov/standards/mets/mets.xsd http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-3.xsd" xmlns:mets="http://www.loc.gov/METS/" xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><mets:metsHdr CREATEDATE="2026-07-07T07:51:56Z"><mets:agent ROLE="CUSTODIAN" TYPE="ORGANIZATION"><mets:name>Repositori BKPK</mets:name></mets:agent></mets:metsHdr><mets:dmdSec ID="DMD_eprint_2926_mods"><mets:mdWrap MDTYPE="MODS"><mets:xmlData><mods:titleInfo><mods:title>74 Pengaruh Kombinasi Vitamin C dan E Dosis Tinggi  terhadap Penurunan Sistem Hemopoetik Penderita Kanker Kepala dan Leher yang Mendapat Kemoterapi Platin</mods:title></mods:titleInfo><mods:name type="personal"><mods:namePart type="given">Yusuf</mods:namePart><mods:namePart type="family">Aminullah</mods:namePart><mods:role><mods:roleTerm type="text">author</mods:roleTerm></mods:role></mods:name><mods:abstract>Cisplatin dapat menyebabkan penurunan sistem hemopoetik M akibat Radical oxygen spesies (ROS) pada penderita kanker kepala dan leher (KKL). Kombinasi vitamin C dan E dosis tinggi sebagai antioksidan dari luar diperlukan untuk menetralisir ROS.      Tujuan penelitian membuktikan bahwa kombinasi vitamin C dan E dosis tinggi dapat mengurangi penurunan sistem hemopoetik penderita KKL akibat cisplatin.       Penelitian pre-post test design. Subyek yang memenuhi kriteria inklusi dari klinik dan bangsal THT-KL RSUP Dr. Kariadi Semarang dilakukan  randomisasi blok, kemudian dibagi dua kelompok; kelompok perlakuan diberikan kombinasi vitamin C 1000 mg dan E 400 mg dan kelompok kontrol  diberikan vitamin C 2x50 mg selama 5 minggu. Data dianalisis dengan chi square, paired t test dan independent t-test.       Hasil penelitian menunjukkan empat puluh delapan subyek memenuhi kriteria inklusi, usia terbanyak 50-59 (35,6%) tahun, laki-laki dan perempuan 3 : 1, KNF 32(71,1%), stadium IV 27(60%). Terdapat penurunan hemoglobin dan lekosit yang bermakna antara kedua kelompok (p&lt;0,05), sedangkan penurunan eritrosit dan trombosit tidak 1 t  berbeda bermakna (p&gt;0,05).      Kombinasi vitamin C dan E dosis tinggi dapat mengurangi  penurunan kadar hemoglobin dan jumlah lekosit penderita KKL akibat cisplatin.</mods:abstract><mods:classification authority="lcc">QM Human anatomy</mods:classification><mods:originInfo><mods:dateIssued encoding="iso8601">2014</mods:dateIssued></mods:originInfo><mods:originInfo><mods:publisher>Sekretariat Badan Litbang Kesehatan</mods:publisher></mods:originInfo><mods:genre>Article</mods:genre></mets:xmlData></mets:mdWrap></mets:dmdSec><mets:amdSec ID="TMD_eprint_2926"><mets:rightsMD ID="rights_eprint_2926_mods"><mets:mdWrap MDTYPE="MODS"><mets:xmlData><mods:useAndReproduction>
<p xmlns="http://www.w3.org/1999/xhtml"><strong>For work being deposited by its own author:</strong>
In self-archiving this collection of files and associated bibliographic
metadata, I grant Repositori BKPK the right to store
them and to make them permanently available publicly for free on-line.
I declare that this material is my own intellectual property and I
understand that Repositori BKPK does not assume any
responsibility if there is any breach of copyright in distributing these
files or metadata. (All authors are urged to prominently assert their
copyright on the title page of their work.)</p>

<p xmlns="http://www.w3.org/1999/xhtml"><strong>For work being deposited by someone other than its
author:</strong> I hereby declare that the collection of files and
associated bibliographic metadata that I am archiving at
Repositori BKPK is in the public domain. If this is
not the case, I accept full responsibility for any breach of copyright
that distributing these files or metadata may entail.</p>

<p xmlns="http://www.w3.org/1999/xhtml">Clicking on the <em>Deposit Item Now</em> button indicates your agreement to these
terms.</p>
    </mods:useAndReproduction></mets:xmlData></mets:mdWrap></mets:rightsMD></mets:amdSec><mets:fileSec></mets:fileSec><mets:structMap><mets:div DMDID="DMD_eprint_2926_mods" ADMID="TMD_eprint_2926"></mets:div></mets:structMap></mets:mets>