<mets:mets OBJID="eprint_3996" LABEL="Eprints Item" xsi:schemaLocation="http://www.loc.gov/METS/ http://www.loc.gov/standards/mets/mets.xsd http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-3.xsd" xmlns:mets="http://www.loc.gov/METS/" xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><mets:metsHdr CREATEDATE="2026-07-05T16:40:51Z"><mets:agent ROLE="CUSTODIAN" TYPE="ORGANIZATION"><mets:name>Repositori BKPK</mets:name></mets:agent></mets:metsHdr><mets:dmdSec ID="DMD_eprint_3996_mods"><mets:mdWrap MDTYPE="MODS"><mets:xmlData><mods:titleInfo><mods:title>Laporan Penelitian Toksisitas Tanaman Obat Toga Yang Mengandung Alkaloid 1982-1983</mods:title></mods:titleInfo><mods:name type="personal"><mods:namePart type="given">Bambang</mods:namePart><mods:namePart type="family">Wahjoedi</mods:namePart><mods:role><mods:roleTerm type="text">author</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart type="given">Vincent</mods:namePart><mods:namePart type="family">Vincent</mods:namePart><mods:role><mods:roleTerm type="text">author</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart type="given">B.P</mods:namePart><mods:namePart type="family">Nurendah</mods:namePart><mods:role><mods:roleTerm type="text">author</mods:roleTerm></mods:role></mods:name><mods:abstract>Direktorat Pengawasan obat Tradisional, Direktorat Jenderal Pengawasan Obat da~ Hakanan, Departemen Kesehatan R.I. telah mengusulkan 106 tanaman sebagai Taman·Obat Keluarga (TOGA). Diantara tanaman  obat tersebut termasuk fami1i-famili yang mengandung alkaloida. Berhubung alkaloida termasuk bahan bahan yang keras, maka perlu diperiksa toksisitas akut dan subkroniknya untuk mencegah terhadap pengaruh negatip pada manusia. Dua puluh tanaman yang diperoleh dari Balai Penelitian Tanaman Obat Tawangmangu diperiksa daya toksisitas akutnya menurut cara Weil,C.S.(l952) untuk, menentukan LD50. Dua di antara keduapuluh tanaman di atas, yaitu daun Wungu dan daun Kucai diperiksa daya toksisitas subkroniknya dengan cara memberikan infus bahan·tersebut setiap hari selama·1 bulan, 3 bulan dan 6 bulan (WHO-TRS; 1975) kepada hewan percobaan tikus putih (rat). &#13;
Ternyata berdasarkan kriteria menurut CleasQn (1969), LD50 keduapuluh tanaman  setelah diekstrapolasi untuk tikus (rat) per oral, tergolong bahan yang "Practically Non Toxic11 (PNT). Selanjutnya pada pemeriksaan toksisitas subkronik, tidak terlihat pengaruh negatip terhadap organ-organ vital yang diperiksa seperti : Paru-paru, jantung, hati, limpa, pancreas, ginjal, usus dan lambung,  baik secara makroskopik maupun mikroskopik.</mods:abstract><mods:classification authority="lcc">QV 701-835 Pharmacy and Pharmaceutics</mods:classification><mods:originInfo><mods:publisher>Pusat Penelitian  Farmasi</mods:publisher></mods:originInfo><mods:genre>Monograph</mods:genre></mets:xmlData></mets:mdWrap></mets:dmdSec><mets:amdSec ID="TMD_eprint_3996"><mets:rightsMD ID="rights_eprint_3996_mods"><mets:mdWrap MDTYPE="MODS"><mets:xmlData><mods:useAndReproduction>
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