Repositori BKPKLaporan Penelitian Toksisitas Sub-Kronik Tanaman Obat Indonesia 1986-1987BambangWahjoediauthorMasih banyak rakyat Indonesia mengobati diri sendiri penyakit kencing batu menggunakan tanaman obat, antara lain : Meniran (Phvl lanthus niruri L.), Daun Urat (Plantago major L.), Kumis kucing(Orthosiphon stamineus Benth) dan Gempur batu (Borreria hispida Schum). Sebagaimana diketahui sifat pengobatan penyakit kencing batu adalah lama dan harus terus-menerus sedang data toksisitas subkronik tanaman obat tersebut di atas belum diketahui. Oleh karena itu perlu dilakukan penelitian untuk mengetahui daya racun atau toksisitas secara subkronik selama 3 bulan terus menerus pada he1wan percobaan tikus putih strain IMR (Wistar derived). Hasil percobaan Sampai dengan dosis (40 -50) x Dosis fvlanusia, ke-4 tanaman obat tersebut yang diteliti toksisitas subkroniknya pada tikus percobaan selama 3 bulan dan pemberian bahan secara oral, tidak menunjukkan kelainan-kelainan yang bersifat toksik terhadap 9 macam organ penting tubuh tikus percobaan (hati, paru, jantung, ginjal, lambung, usus, pancreas, limpa dan testes).QV 701-835 Pharmacy and Pharmaceutics1987Pusat Penelitian dan Pengembangan FarmasiMonograph

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