?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F4211%2F&rft.title=Laporan+Proyek+Penelitian+Keamanan+dan+Khasiat+Obat+Asli+1976-1977&rft.creator=Dzulkarnain%2C+B.&rft.subject=QV+701-835+Pharmacy+and+Pharmaceutics&rft.description=Using+the+method+of+Weil%2C+C.S.+the+LD50+of+Anacardium+occidentale+LINN+leaves%2C+Aegle+marmelos+CORR.+leaves+and+stembark%2C+Acorus+calamus+LINN+rhizome%2C+Desmodium+triquetrum+D.C.+leaves+extract+has+been+determined+on+the+mice+to+evaluate+their+toxicity.+Evaluated+by+using+the+Creterion+of+Cleason+it+was+seen+that+all+are+%22Practically+Non+Toxic%22.+The+bitter+cassave+juice+at+dose+2%2C5+ml+per+rat+administered+orrally+did+not+kill+the+rat.%0D%0A%0D%0AAegle+marmelos+CORR+leaves+and+stembark%2C+Acorus+calamus+LINN.+rhizome%2C+Desmodium+triquetrum+D.C.+leaves+extract+were+checked+on+the+cat+blood+pressure+using+the+method+of+Modi+and+Desmauker+it+was+determined+that+none+of+them+were+intersted+for+further+examination.%0D%0A%0D%0AThe+influence+of+the+extract+of+A.+occidentale+LINN.+leaves%2C+A+marmelos+CORR.+leaves+and+stembark%2C+A.+calamus+LINN.+rhizome+and+D+triquetrum+D.C.+leaves+were+tested+on+the+isolated+rabbit+intestine+and+guinea+pig+isolated+uterus.+It+was+seen+that+A.+occidentale+LINN.%2C+A.+marmelos+CORR.+has+no+consistent+effect+while+D+triquetrum+D.C.+has+a+stimulating+effect+which+was+blocked+partly+by+Avil+and+partly+by+Atropine.+A.+calamus+having+a+depressant+effect+on+the+intestine+proved+to+be+Atropine+-+like.+This+supports+the+use+of+A.+calamus+LINN.+as+antidysentric+agent+as+long+as+the+motility+is+concerned.+It+also+has+a+depressive+effect+on+the+isolated+uterus.+%0D%0A%0D%0AThe+extract+of+A.+marmelos+CORR.+leaves+and+stembark+have+a+stimulating+effect+on+the+isolated+guinea+pig+uterus+which+supports+the+information+being+an+abortive+agent.%0D%0AThe+stimulating+effect+of+A.+occidentale+LINN.+to+be+isolated+intestine+and+uterus+might+be+partly+due+to+the+anacardic+acid+content+which+is+known+being+a+purgative.&rft.publisher=Pusat+Penelitian+Farmasi&rft.date=1977&rft.type=Monograph&rft.type=NonPeerReviewed&rft.format=text&rft.language=id&rft.identifier=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F4211%2F1%2FLaporan%2520Proyek%2520Penelitian%2520Keamanan%2520dan%2520Khasiat%2520Obat%2520Asli%25201976-1977.pdf&rft.identifier=++Dzulkarnain%2C+B.++(1977)+Laporan+Proyek+Penelitian+Keamanan+dan+Khasiat+Obat+Asli+1976-1977.++Project+Report.+Pusat+Penelitian+Farmasi%2C+Jakarta.++++(Unpublished)++