?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F4346%2F&rft.title=Laporan+Riset+IPTEKKES+2019+Profil+Imunoekspresi+C-X-C+Chemokine+Receptor+Type+4+(CXCR4)%2C+Mammalian+Target+of+Rapamycin+(mTOR)%2C+Nuclear+Factor+kB+(NF-kB)%2C+dan+Programmed+Death+Ligand+(PD-L1)+pada+Pasien+Limfoma+Non-Hodgkin+tipe+Diffuse+Large+B-cell+di+RSUP+Dr.+Hasan+Sadikin&rft.creator=Dewayani%2C+Birgitta+M.&rft.creator=Yulianti%2C+Herry&rft.creator=Riani%2C+Fety&rft.creator=Purnomo%2C+Bhayu+Chandra&rft.subject=WH+120-540+Hematologic+Diseases.+Immunologic+Factors.+Blood+Banks&rft.description=Limfoma+non-Hodgkin+tipe+diffuse+large+B+cell+(LNH+tipe+DLBC)+adalah+LNH+yang+paling+sering+terjadi+di+seluruh+dunia.+Pengobatan+rituximab%2C+cyclophosphamide%2C+hydroxydaunorubicin+(doxorubicin)%2C+oncovin+(vincristine)%2C+and+prednisone+(R-CHOP)+saat+ini+merupakan+terapi+standar+untuk+LNH+tipe+DLBC.+Walaupun+demikian+terjadi+refractory+pada+10%25+kasus+pada+penderita+LNH+tipe+DLBC+walaupun+telah+mendapat+terapi+R-CHOP+sehingga+memiliki+prognosis+yang+lebih+buruk.+Untuk+meningkatkan+angka+kesembuhan+dan+harapan+hidup+pasien+LNH+tipe+DLBC+saat+ini+sedang+dikembangkan+terapi+target%2C+di+antaranya+inhibitor%0D%0Aterhadap+C-X-C+chemokine+receptor+type+4+(CXCR4)%2C+mammalian+target+of+rapamycin+(mTOR)%2C+nuclear+factor-kB+(NF-kB)%2C+dan+imunoterapi+anti+programmed+death+ligand+1+(PD-L1).+Penelitian+ini+ditujukan+untuk+melihat+gambaran+ekspresi+dan+relevansi+klinis+keempat+biomarker+tersebut+pada+populasi+pasien+LNH+tipe+DLBC+di+Indonesia.%0D%0APenelitian+ini+melibatkan+60+kasus+baru+yang+didiagnosis+sebagai+LNH+tipe+DLBC+di+RSUP+Dr.+hasan+Sadikin+Bandung+selama+periode+Januari+2015+hingga+Agustus+2019.+Pemeriksaan+imunohistokimia+(IHK)+CXCR4%2C+mTOR%2C+Nf-kB%2C+dan+PD-L1+dilakukan+pada+blok+parafin+massa+tumor+pasien.+Data+klinis+diperoleh+dari+berkas+rekam+medis.%0D%0AImunoekspresi+CXCR4+tinggi+sebanyak+30+kasus+(50%2C0%25)%2C+imunoekspresi+NF-kB+tinggi+hanya+sebanyak+1+kasus+(1%2C7%25)%2C+sedangkan+imunoekspresi+PD-L1+tinggi+sebanyak+16+kasus+(26%2C7%25).+Terdapat+hubungan+yang+signifikan+antara+imunoekspresi+CXCR4+dengan+keterlibatan+lebih+dari+satu+organ+ekstranodal+(p%3D0%2C007)+dan+gejala+B+(p+%3D+0%2C037).%0D%0AImunoekspresi+CXCR4%2C+mTOR%2C+NF-kB%2C+dan+PD-L1+tinggi+terdeteksi+pada+sebagian+kasus+LNH+tipe+DLBC+pada+populasi+pasien+LNH+tipe++DLBC+di+RSUP+Dr.+Hasan+Sadikin+Bandung.+Imunoekspresi+CXCR4%2C+mTOR%2C+NF-kB+dan+PD-L1++secara+umum+tidak+berhubungan+secara+signifikan+dengan+berbagai+karakteristik+klinis+pada+pasien+LNH+tipe+DLBC+di+RSUP+Dr.+Hasan+Sadikin+Bandung%2C+kecuali+imunoekspresi+CXCR4+yang+berhubungan+secara+signifikan+dengan+keterlibatan+organ+ekstranodal+%3E1+dan+gejala+B&rft.publisher=Badan+Penelitian+dan+Pengembangan+Kesehatan+dan+FK+Universitas+Padjadjaran&rft.date=2019&rft.type=Monograph&rft.type=NonPeerReviewed&rft.format=text&rft.language=id&rft.identifier=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F4346%2F1%2FLaporan%2520Riset%2520IPTEKKES%25202019%2520Profil%2520Imunoekspresi%2520C-X-C%2520Chemokine%2520Receptor%2520Type%25204%2520%2528CXCR4%2529%252C%2520Mammalian%2520Target%2520of%2520rapamycin%2520%2528mTor%2529%252C%2520Nuclear%2520Factor%2520kB%2520%2528NF-kB%2529%252C%2520dan%2520programmed%2520death%2520Ligand%2520%2528PD-L1%2529%2520pada%2520Pasien%2520Limfoma%2520Non-Hodgkin.pdf&rft.identifier=++Dewayani%2C+Birgitta+M.+and+Yulianti%2C+Herry+and+Riani%2C+Fety+and+Purnomo%2C+Bhayu+Chandra++(2019)+Laporan+Riset+IPTEKKES+2019+Profil+Imunoekspresi+C-X-C+Chemokine+Receptor+Type+4+(CXCR4)%2C+Mammalian+Target+of+Rapamycin+(mTOR)%2C+Nuclear+Factor+kB+(NF-kB)%2C+dan+Programmed+Death+Ligand+(PD-L1)+pada+Pasien+Limfoma+Non-Hodgkin+tipe+Diffuse+Large+B-cell+di+RSUP+Dr.+Hasan+Sadikin.++Project+Report.+Badan+Penelitian+dan+Pengembangan+Kesehatan+dan+FK+Universitas+Padjadjaran%2C+Jakarta.++++(Unpublished)++