?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F45%2F&rft.title=Therapy+of+Uncomplicated+Falciparum++Malaria+%3A+A+Randomized+Trial+Comparing+Artesunate+Plus+Sulfadoxine-Pyrimethamine+Versus+Sulfadoxine-Pyrimethamine+Alone+in+Irian+Jaya%2C+Indonesia&rft.creator=Tjitra%2C+Emiliana&rft.subject=WC+680-950+Tropical+and+Parasitic+Diseases&rft.description=Combining+artesunate+with+existing+antimalaria+drugs+may+improve+cure+rates%2C+delay+emergence+of+resistance%2C+and+reduce+transmisison.+We+performend+a+randomized+comparative+trial+to+quantify+the+effect++of+adding+artesunate+to+sulfadoxine-pyrimethamine+in++the+treatment+of+uncomplicated+falciparum+malaria+in+Indonesia.+++Using+a+modified+1997+World+Health+Organization+protocol+for+assessment+of+therapeutic+efficacy+of+antimalaria+drugs%2C+105+patients+(stratified+by+age%2Fethnic+group)+were+randomized%3A+53+received+artesunate+orally+4+mg%2Fkg+of+body+weight%2C+a+single+daily+dose+for+three+days%2C+plus+sulfadoxine-pyrimethamine+orally+(1.25+mg+of+pyrimethamine%2Fkg+of+body+weight)%2C+a+single+dose+on+day+0+and+52+patients+received+sulfadoxine-+pyrimethamine+alone.+Six+from+the+combination+group+were+withdrawn+from+analysis%2C+as+were+six+of+the+sulfadoxine-pyrimethamine+group.+++Treatment+failure+rates+on+day+14+were+0%25in+the+artesunate+plus+sulfadoxine-pyrimethamine+group+and+8.7%25+in+the+sulfadoxine-pyrimethamine+group+(P%3D0.12).+Treatment+failure+rates+on+day+28+were+4.4%25+and+15.2%25%2C+respectively+(P%3D0.16).+Relative+risk+of+treatment+failure+at+28+day+was+0.3+(95%25+confidence+inteval+%5BCI%5D%3D0.1%26%238211%3B1.3).+Mean+fever+clearance+time+(1.3+versus+1.7+days)+and+mean+parasite+clearance+time+(1.4+versus+2.0+days)+were+both+faster+in+the+artesunate+plus+sulfadoxine-pyrimethamine+group+than+in+the++sulfadoxine-pyrimethamine+group+(+P%3D0.08+and+P+%3C+0.0001%2C+respectively).+Only+20+(39.2)+of+51+patients++treated+with+artesunate+plus+sulfadoxine-pyrimethamine+were+still+parasitemic+on+day+1+compared+with+45+(86%2C5%25)+of+52+patients+treated+with+sulfadoxine-pyrimethamine+alone++(P+%3D+0.000001%2C+relative+risk+%5BRR%5D%3D0.4%2C95%25+CI%3D0.3-0.6).+Gametocyte+carriage+was++lower+following+artesunate+plus+sulfadoxine-pyrimethamine+than+following+sulfadoxine-pyrimethamine++(RR%3D0.5%2C+95%25+CI%3D0.2-1.0+on+day+7+and+RR+%3D+0.5%2C+95%25+CI%3D0.2-1.1+on+day+14+).+++Mild+diarrhea%2C+rash+and+itching+resolved+without+treatment.+Combined+artesunate+plus+sulfadoxine-+pyrimethamine+resulted+in+more+rapid+fever+and+parasites+clearance%2C+was+well+tolerated%2C+reduced+risk+of+treatment+failure%2C+and+lowered+gametocyte+carriage.&rft.publisher=Pusat+Penelitian+dan+Pengembangan+Pemberantasan+Penyakit&rft.date=2001&rft.type=Monograph&rft.type=NonPeerReviewed&rft.identifier=++Tjitra%2C+Emiliana++(2001)+Therapy+of+Uncomplicated+Falciparum+Malaria+%3A+A+Randomized+Trial+Comparing+Artesunate+Plus+Sulfadoxine-Pyrimethamine+Versus+Sulfadoxine-Pyrimethamine+Alone+in+Irian+Jaya%2C+Indonesia.++Project+Report.+Pusat+Penelitian+dan+Pengembangan+Pemberantasan+Penyakit.+++++