?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F4646%2F&rft.title=Kelainan+Patalogi+pada+Mencit+dan+Tikus+Disebabkan+Zat+Warna+Rhodamine+B+dan+Metanil+Yellow&rft.creator=Nio%2C+Oey+Kam&rft.creator=Hong%2C+Lie+Goan&rft.creator=Herlinda%2C+J.&rft.creator=Aminah%2C+Risnawati&rft.subject=QV+Pharmacology&rft.description=Rhodamine+B+and+Metanil+Yellow+are+2+non+edible+dyestuff+which+are+widely+used+for+coloring+snacks+and+drinks+in+Jakarta.+These+substances+are+reportedly+toxic+for+human+beings%2C+however+no+data+on+the+acute+or+chronic+intoxications+are+available+so+far.%0D%0A%0D%0AGroups+of+mice+and+rats+were+fed+with+either+Rhodamine+B+or+Metanil+Yellow.The+doses+of+these+dyestuffs+varied+from+0%2C5+mg+to+1350+mg+per+kilogram+body+weight.+These+animals+were+divided+into+3+different+experimental+groups%2C+respectively+acute%2C+subacute+and+chronic+toxicity+tests.%0D%0A%0D%0AClinical+signs+included+discoloration+of+the+skin+and+its+intensity+depend+upon+the+concentration+of+the+dyestuffs+used.+The+body+weight+gain+of+the+test+animals+were+consistently+lower+than+those+of+the+controls.+Some+animals+became+aggressive+and+canibalism+accrued.+Pathological+lesions+consisted+of+unthriftiness%2C+focal+liver+inflammation%2C+hydronephrosis%2C+hepatoma+and+lymphoma.%0D%0A%0D%0AConsidering+the+results+of+the+experiments%2C+it+is+justified+to+warn+that+the+wide+use+of+Rhodamine+B+and+Metanil+Yellow+for+food+coloring%2C+which+might+be+hazardous+for+human+health.&rft.publisher=Badan+Penelitian+dan+Pengembangan+Kesehatan&rft.date=1982&rft.type=Monograph&rft.type=NonPeerReviewed&rft.format=text&rft.language=id&rft.identifier=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F4646%2F1%2FGIZ-15-KELAINAN%2520PATOLOGI%2520PADA%2520MENCIT%2520DAN%2520TIKUS%2520DISEBAKAN%2520ZAT%2520RHODAMINE%2520B%2520DAN%2520METANIL%2520YELLOW.PDF&rft.identifier=++Nio%2C+Oey+Kam+and+Hong%2C+Lie+Goan+and+Herlinda%2C+J.+and+Aminah%2C+Risnawati++(1982)+Kelainan+Patalogi+pada+Mencit+dan+Tikus+Disebabkan+Zat+Warna+Rhodamine+B+dan+Metanil+Yellow.++Project+Report.+Badan+Penelitian+dan+Pengembangan+Kesehatan%2C+Jakarta.++++(Unpublished)++