TY  - JOUR
A1  - Gitawati, Retno
UR  - http://www.badankebijakan.kemkes.go.id/repositori/id/eprint/5451/
ID  - bkpkkemkes5451
TI  - INTERAKSI OBAT DAN BEBERAPA IMPLIKASINYA
EP  - 184
IS  - 4
SP  - 175
AV  - public
PB  - Sekretariat Badan Penelitian dan Pengembangan Kesehatan
KW  - drug-drug interaction. adverse effect
KW  -  pharmacokinetics
KW  -  pharmacodynamics
SN  - 0853-9987
N2  - Drug-drug interactions can initiate undesirable or adverse effects. This could have a clinical implication and could also become serious health problems. Since a large number of drugs are introduced and marketed every year, new interactions between concomitant medications might possibly increase. The safety profile of drugs including the impacts of drug-drug interactions can be provided from pharmacoepidemiology and pharmacovigilance data. There are some mechanisms of drug-dug interactions, i.e. pharmaceutics interaction, pharmacokinetics and pharmacodynamics interactions. However, only pharmacodynamic interaction can be predicted and the effect usually applies equally to any drugs In the same class therapy. On the other hand, pharmacokinetic interactions cannot be predicted or extrapolated to any drugs in the same class therapy because of differences in their pharmacokinettcs profiles. Information on how is the mechanism of drug-drug interaction is needed, so the possible adverse effect due to drug-drug interactions can be anticipated.
JF  - Media Penelitian dan Pengembangan Kesehatan
VL  - 18
Y1  - 2008/12//
ER  -