<mets:mets OBJID="eprint_5823" LABEL="Eprints Item" xsi:schemaLocation="http://www.loc.gov/METS/ http://www.loc.gov/standards/mets/mets.xsd http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-3.xsd" xmlns:mets="http://www.loc.gov/METS/" xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><mets:metsHdr CREATEDATE="2026-07-05T06:23:21Z"><mets:agent ROLE="CUSTODIAN" TYPE="ORGANIZATION"><mets:name>Repositori BKPK</mets:name></mets:agent></mets:metsHdr><mets:dmdSec ID="DMD_eprint_5823_mods"><mets:mdWrap MDTYPE="MODS"><mets:xmlData><mods:titleInfo><mods:title>TELAAH ANTI KLASTOGENIK EKSTRAK KASAR RIMPANG KENCUR (KAEMPFERIA galanga L.) TERHADAP AKTIVITAS KLASTOGENIK MITOMISIN C PADA ERITROSIT POLIKROMATIK MENCIT</mods:title></mods:titleInfo><mods:name type="personal"><mods:namePart type="given">Setiorini</mods:namePart><mods:namePart type="family">Setiorini</mods:namePart><mods:role><mods:roleTerm type="text">author</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart type="given">Anom</mods:namePart><mods:namePart type="family">Bowolaksono</mods:namePart><mods:role><mods:roleTerm type="text">author</mods:roleTerm></mods:role></mods:name><mods:abstract>Penelitian ini dilakukan untuk mengetahui potensi antiklastogenik rimpang kencur terhadap alctivitas klastogenik mitomicin C eritrosit polikromatik mencit. Penelitian ini menggunakan uji mikronukleus 30 ekor mencit (Mus musculus L.) jantan galur Swiss yang dibagi menjadi 6 kelompok perlakuan, masing-masing 5 ulangan. Perlakuan I adalah kontrol, yaitu mencit yang diberi dengan akuades murni. Perlakuan II, III, IV, V, dan VI yaitu mencit yang diberi ekstrak kencur dengan dosis berturut-turut 6,25; 12,5; 25; 50; dan 100 mg/kg berat badan (bb). Mulut mencit diberi ini selama 7 hari berturut-turut, Pada hari ke-8 mencit-mencit tersebut disuntik dengan mitomicin C (MMC) secara intra peritoneal sebanyak 1,5 mg/kg bb dan dibiarkan selama 30 jam. Setelah itu dibuat sediaan sumsum tulang. Hasil penelitian ini menyimpulkan bahwa ekstrak rimpang kencur dengan dosis 6,25; 12,5; 25; dan 50 mg/kg BB dapat menghambat kerusakan sitogenetik yang diinduksi oleh MMC pada eritrosit polikromatik sumsum tulang  mencit. Sedangkan, dosis JOO mg/kg bb tidak menyebabkan penurunan mikronukleus.</mods:abstract><mods:classification authority="lcc">SF Animal culture</mods:classification><mods:originInfo><mods:dateIssued encoding="iso8601">2001</mods:dateIssued></mods:originInfo><mods:originInfo><mods:publisher>Sekretariat Badan Penelitian dan Pengembangan Kesehatan</mods:publisher></mods:originInfo><mods:genre>Article</mods:genre></mets:xmlData></mets:mdWrap></mets:dmdSec><mets:amdSec ID="TMD_eprint_5823"><mets:rightsMD ID="rights_eprint_5823_mods"><mets:mdWrap MDTYPE="MODS"><mets:xmlData><mods:useAndReproduction>
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