?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F5918%2F&rft.title=Pengembangan+Ekstrak+Daun+Waru+(Hibiscus+similis+L)+dan+Pegagan+(Centella+asiatica+L)+sebagai+Fitofarmaka+Antituberkulosis+%3A+Tahap+I%3A+Uji+Aktivitas+Antimikobakterium%2C+Sistem+Imun%2C+dan+Karakterisasi+Ekstrak&rft.creator=Nugroho%2C+Yun+Astuti&rft.creator=Winarsih%2C+Winarsih&rft.subject=RS+Pharmacy+and+materia+medica&rft.subject=WB+Practice+of+Medicine&rft.description=Tanaman+Waru+(Hibiscus+similis+L)%2C+Kaki+kuda+atau+Pegagan+(Centella+asiatica+L)+secara+tradisional+dipakai+untuk+pengobatan+penyakit+tuberkulosis%2C+dapat+meningkatkan+sistem+kekebalan+tubuh.+Oleh+karena+itu+telah+dilakukan+%22Uji+aktivitas+antimikobakterium%2C+sistem+imun+dan+karakterisasi+ekstrak%22.%0D%0A%0D%0AMetode+penelitian%2C+standarisasi+menggunakan+pedoman+dari+Badan+POM+(2000)%2C+uji+khasiat+antimikobakterium+menggunakan+metode+konsentrasi+absolut+(2001)+dan+uji+imunitas+menggunakan+metode+RID+(Radial+Immunodiffussion%2C+1977).%0D%0A%0D%0AHasil+penelitian%2C+ekstraksi+daun+Waru+menghasilkan+rendemen+sebesar+21%25+dan+hasil+karakterisasi+non+spesifik+(%25)%2C+kadar+abu+6%2C16%3B+kadar+abu+larut+air+5%2C05%3B+kadar+abu+tidak+larut+asam+0+dan+kadar+air+16%2C08.+Karakterisasi+spesifik+(%25)%2C+kadar+sari+larut+air+47%2C10%3B+kadar+sari+larut+dalam+etanol+14%2C82%3B+kadar+tanin+7%2C92.+Golongan+kimia+yang+diperoleh+dari+ekstrak+daun+Waru+adalah+alkaloid+dan+tanin.+Ekstraksi+herba+Pegagan+menghasilkan+rendemen+sebesar+8%2C4%25+dan+hasil+karakterisasi+non+spesifik+(%25)%2C+kadar+abu+9%2C71+%3B+kadar+abu+larut+air+6%2C18%3B+kadar+abu+tidak+larut+asam+0%2C55+dan+kadar+air+6%2C39.+Karakterisasi+spesifik+(%25)%2C+kadar+sari+larut+air+34%2C50%3B+kadar+sari+larut+dalam+etanol+10%2C44%3B+kadar+asiatikosida+1%2C00.+Golongan+kimia+yang+diperoleh+dari+ekstrak+herba+Pegagan+adalah+saponin%2C+steroid%2C%0D%0Atriterpen%2C+glikosida%2C+alkaloid%2C+tanin%2C+flavonoid.%0D%0A%0D%0AUji+khasiat+antibakteri%2C+ekstrak+daun+Waru+36+mg%2Fml+bakteri+tuberkulosis+strain+Mycobacterium+tuberculosis+H37RV+pada+media+L-J+dan+7H10+agar+menunjukkan+adanya+hambatan+tapi+untuk+strain+Mycobacterium+tuberculosis+MOR+tidak+ada+hambatan.+Ekstrak+herba+Pegagan+22%2C5+mg%2Fml+untuk+strain+Mycobacterium+tuberculosis+H37RV+pada+media+L-J+dan+7H10+agar+menunjukkan+adanya+hambatan+tapi+untuk+strain+Mycobacterium+tuberculosis+MOR+tidak+ada+hambatan.%0D%0A%0D%0AUji+imunomodulator%2C+kenaikan+kadar+IgG+setelah+pemberian+ekstrak+daun+Waru+dosis+4%3B+12+dan+36+mg%2F20+g+bb+pada+mencit+yang+diinduksi+SDMD+1+%25+adalah+76%2C25%3B+169%2C25+dan+310%2C37+mg%2Fdl.+Ekstrak+daun+Waru+dosis+36mg%2F20+g+bb+mempunyai+potensi+yang+sama+dengan+Vitamin+A+dosis+4000+UI%2F20+g+bb+(p%3D0%2C407)+dalam+menaikkan+kadar+IgG.+Pemberian+ekstrak+herba+Pegagan+dosis+2%2C5%3B+7%2C5+dan+22%2C5+mg%2F20+g+bb+dapat+meningkatkan+kadar+IgG+sebesar+82%2C00%3B+148%2C62+dan+361%2C25+mg%2Fdl.+Ekstrak+herba+Pegagan+dosis+22%2C+5mg%2F20+g+bb+khasiatnya+sebanding+dengan+Vitamin+A+dosis+400+UI%2F20+g+bb+(p%3D0%2C684%7D+dalam+meningkatkan+kadar+IgG+mencit+yang+diinduksi+SDMD+1+%25.%0D%0A%0D%0AKesimpulan%2C+ekstrak+daun+Waru+(Hibiscus+similis+L)+dan+herba+Pegagan+dapat+menghambat+pertumbuhan+Mycobacterium+tuberculosis+strain+H37VR.+Ekstrak+daun+Waru+(Hibiscus+similis+L)+dosis+36+mg%2F20+g+bb+dapat+meningkatkan+kadar+lgG+sebesar+310%2C375+mg%2Fdl.+Ekstrak+herba+Kaki+Kuda%2FPegagan+(Centella+asiatica+L)+dosis+22%2C5+mg%2Fdl+%0D%0Adapat+meningkatkan+kadar+IgG+sebesar+361%2C25+mg%2Fdl.&rft.publisher=Badan+Penelitian+dan+Pengembangan+Kesehatan&rft.date=2003&rft.type=Monograph&rft.type=NonPeerReviewed&rft.format=text&rft.language=en&rft.identifier=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F5918%2F1%2FFAR-417A-PENGEMBANGAN%2520EKSTRAK%2520DAUN%2520WARU%2520DAN%2520PEGAGAN%2520SEBAGAI%2520FITOFARMAKA%2520ANTITUBERKULOSIS.pdf&rft.identifier=++Nugroho%2C+Yun+Astuti+and+Winarsih%2C+Winarsih++(2003)+Pengembangan+Ekstrak+Daun+Waru+(Hibiscus+similis+L)+dan+Pegagan+(Centella+asiatica+L)+sebagai+Fitofarmaka+Antituberkulosis+%3A+Tahap+I%3A+Uji+Aktivitas+Antimikobakterium%2C+Sistem+Imun%2C+dan+Karakterisasi+Ekstrak.++Project+Report.+Badan+Penelitian+dan+Pengembangan+Kesehatan.+++++