?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F64%2F&rft.title=Detection+of+Histidine+Rich+Protein+2+and+Panmalarial+ICT+Malaria+Pf%2FPv+Test+Antigens+after+Chloroquine+Treatment+of+Uncomplicated+Falciparum+Malaria+Does+Not+Reliably+Predict+Treatment+Outcome+in+Eastern+Indonesia&rft.creator=Tjitra%2C+Emiliana&rft.subject=QU+55-70+Proteins.+Amino+Acids.+Peptides&rft.description=In+regions+with+drug-resistant+malaria%2C+the+ability+to+rapidly+detect+or+predict+treatment+failure+(TF)+soon+after+a+course+of+standard+therapy+for+Plasmodium+falciparum+malaria+would+facilitate+the+prompt+institution+of+second-line+therapy.+We+thus+evaluated+longitudinally+the+ability+of+the+ICT+Malaria+Pf%2FPv+immunochromatographic+test+to+predict+treatment+outcome.+++Sixty-six+Sumbanese+Indonesians+with+uncomplicated+falciparum+malaria+were+treated+with+chloroquine+and+followed+for+28+days+by+use+of+1997+World+Health+Organization+criteria+for+assessment+of+therapeutic+efficacy+of+antimalaria+drugs.+The++ICT+Pf%2FPv+testing+could+be+compared+with+microscopy+in+approximately+half+of++the+patients+on+each+day+of++follow-up.+Although+strongly+positive+histidine+rich+protein+2+(HRP2)+line+intensities+(equal+to+or+greater+than+the+control+band)+in+convalescence+were+highly+predictive+of+TF%2C+any+degree+of++positivity+for+the+HRP2+and+panmalaria+antigens+in+convalescence+was+only+moderately+predictive+of+TF.+++Positive+predictive+values+of+the+HRP2+and++panmalaria++antigens+for+TF+were+76.9%25+and+87%2C0%25%2C+respectively%2C+on+Day+3%2C+82%2C4%25+and+87.5%25+on+day+7%2C+and+78.9%25+and+78.9%25+on+Day+14.+Negative+HRP2+and+panmalaria+antigens+results+in+convalescence+were+even+less+predictive+of+an+adequate+clinical+response%2C+and+false-negative+HRP2+and+panmalaria+antigen+test+results+were+found+in+one-sixth+(6+of+37)+of+recrudescent+infection+diagnosed+by+microscopy+among+patients+with+late+treatment+failure.+++To+reliably+predic+treatment+outcome+with+rapid+antigen+tests%2C+further+development+appears+necessary+to+improve+sensitivity+for++viable+asexual+parasites+while+avoiding+detection+of++both+gametocytes+and+persistent+antigen+in+convalescence.&rft.publisher=Pusat+Penelitian+dan+Pengembangan+Pemberantasan+Penyakit&rft.date=2001&rft.type=Monograph&rft.type=NonPeerReviewed&rft.identifier=++Tjitra%2C+Emiliana++(2001)+Detection+of+Histidine+Rich+Protein+2+and+Panmalarial+ICT+Malaria+Pf%2FPv+Test+Antigens+after+Chloroquine+Treatment+of+Uncomplicated+Falciparum+Malaria+Does+Not+Reliably+Predict+Treatment+Outcome+in+Eastern+Indonesia.++Project+Report.+Pusat+Penelitian+dan+Pengembangan+Pemberantasan+Penyakit.+++++