?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fwww.badankebijakan.kemkes.go.id%2Frepositori%2Fid%2Feprint%2F895%2F&rft.title=Analisis+Gen+Penyandi+Glutation+S-Transferase+Schistosoma+japonicum+(Sj26GST)+Dari+Daerah+Endemis+Schistosomiasis+Napu+dan+Lindu%2C+Sulawesi+Tengah&rft.creator=Nurwidayati%2C+Anis&rft.subject=WC+680-950+Tropical+and+Parasitic+Diseases&rft.description=Schistosomiasis+in+Indonesia+are+found+in+Napu+and+Lindu+highland%2C+Central+Sulawesi.+Schistosomiasis+still+a+public+health+problem+which+its+prevalence+increase+every+year.+The+large+scale+treatment+by+mass+chemotherapy+using+praziquantel+was+done+to+reduce+the+prevalence+of+schistosomiasis+since+1980.++The+objective+of+this+study+was+to+look+for+possible+evidence+of+the+development+of+resistance+in+Schistosoma+japonicum+to+praziquantel+in+endemic+areas.+Field+study+was+conducted+in+endemic+areas+Napu+and+Lindu.+All+of+the+80+stool-positive+subjects+in+Napu+and+60+stool-positive+subjects+in+Lindu%2C+were+treated+with+a+single+dose+of+60+mg%2Fkg+of+praziquantel.+Three+weeks+after+treatment%2C+all+of+the+subjects+were+examined+again+using+the+same+stool+examination.+Moleculer+laboratory+study+was+also+conducted+to+analyse+the+sequences+of+S.japonicum+gluthations+transferase+gene+(Sj26GST).++The+results+showed+that+on+three+weeks+examination+after+treatment%2C+stool-negative+results+were+found+in+all+subjects+which+represents+a+100%25+parasitologic+cure+rate.+All+stool+samples+were+re-examined+six%2C+nine%2C+and+12+weeks+after+the+first+treatment+and+no+stool-positive+subjects+were+found.+The+gene+sequences+analysis+showed+that+the+homology+was+very+high+between+isolate+from+Indonesia+and+several+isolates+from+China+that+known+still+susceptible+to+praziquantel.++From+the+results+indicate+that+there+was+no+evidence+for+reduced+susceptibility+of+S.japonicum+to+praziquantel+despite+its+extensive+use+in+the+endemic+areas+of+Napu+and+Lindu+for+more+than+20+years.&rft.publisher=Balai+Penelitian+dan+Pengembangan+Pengendalian+Penyakit+Bersumber+Binatang+(P2B2)+Donggala&rft.date=2011&rft.type=Monograph&rft.type=NonPeerReviewed&rft.identifier=++Nurwidayati%2C+Anis++(2011)+Analisis+Gen+Penyandi+Glutation+S-Transferase+Schistosoma+japonicum+(Sj26GST)+Dari+Daerah+Endemis+Schistosomiasis+Napu+dan+Lindu%2C+Sulawesi+Tengah.++Project+Report.+Balai+Penelitian+dan+Pengembangan+Pengendalian+Penyakit+Bersumber+Binatang+(P2B2)+Donggala.+++++