Polymerase Basic 2 (PB2) is the longest segment of Avianlnjluenza Virus (AIV) genome. has been known to play a role in cleavage and capping a/RNA, related with replication and transcription into 8 segments of virus genome. This study was aimed to find out the existence of amino acid change in positions 627 and 667 that Glutamate mutation into Lysine in position 627 PB2, determines the high path…
SiRNA is a promising method to deal with viral infections. The principle of siRNA is based on the complementarily of (synthetic) dsRNA to an RNA virus which, in consequence, will be silenced. Many studies are currently examining the effects of siRNA on replication of diverse virus types like Hepatitis C, polio and HIV. The choice of the siRNA target sequence is crucial. It has to be very homolo…
The novel compounds of 2-hydroxynicotinyl octylamide (NOA) were synthesized by modifying of the UK-3A compound known biologically active to inhibit bacterial and cancer cell growth. Synthesis of 2-hydroxynicotinyl octylamide (NOA) were carried out in one step reaction for the second compound. NOA was synthesized by amidation reaction between 2-hydroxynicotinic acid and octylamin yielded 76.1% o…
The purpose of this research is to potency of secondary metabolites extracted ethanol contained in the leaves of Annona squamosa (sweetsop) as immunostimulants in particular broiler chickens against gumboro (like HIV) that provides an alternative antiviral drug that is safer, cheap and easily obtainable in herb-based environment in Indonesia. The ethanol extract of leaves of Annona squamosa as …