In the last few years there are tendency for cancer study to develop in discovery of new chemical entity (NCE) for new drugs. The needed of NCE based on reality that cancer can be used at one therapy and be implemented as a solution to inhibit a resistant level and very useful in recovery time. Natural products are the most important sources of INCE and could be used from plants. Animals or min…
Gamavuton-0 (GVT-0), also nemed as 1,5-bis(4’hydroxy—3-methoxyphenyl)-1-4-pentadiene-3 0ne is a 1,5-diphenyl-1-4-pentadiene-3 one analog of curcumin by modifying the center site of curcumin leading to 1,4-pentadiene-3-ones to maintain the hydroxy moiety at aromatic rings which are responsible for its biological activities. Curcumin has been reported to have potrnt anticarcinogenic effects. …
Eurycomanoms is a cytotoxic ingredient found in Eurycoma longifolia jack .Previous studies have noted its activity against many epithellal cell lines. In this study, eurycomanone had abvious cytotoxic effect on Hela cell by methylene blue staining assays. After HeLa were treated with surycomanone, typical morphological changes, including cytoplasm shrinkage and decrease of cell volume were obse…