Corynebacterium diphtheriae is the causative agent of diphtheria. The main virulence determinant of the bacteria is diphtheria toxin, the cause of the systemic complication seen with diphtheria. Production of diphtheria toxin by toxigenic strain encoded by dtx/tox gene and repressed by dtxR gene. Gold standard for bacterial toxigenicity test carried out by conventional methods (Elek test, Guine…
Diphteria is an acute infection of the upper respiratory tract or skin caused by toxin-producing Corynebacterium diphtheria. It is characterized by a formation of pseudo membrane in the infection sites and a toxic reaction involving primarily the heart and peripheral nerves. The organism usually gains entry through the respiratory tract is mainly spread by respiratory droplet from patients or …
Since 2005 up to 2006 diptheria out break had occur in Tasikmalaya district among 1-15 year old children. Total cases are 55 children with cases died with the Case Family Rate: (CFR) 31,91%. Further on January 2007 the same out break occur in Garut district, with 17 cases die (CFR 11,76%. Research objective is to identify the correlation of housing environmental condition with the diphtheria o…