Apoptosis is an important target on anticancer mechanism. The purpose of this research is to investigate apoptosis induction of Selaginella plana Hieron active fractions on T47D cells. Absolute ethanol was used to extract Selaginella /Diana powders. Ethanolic extract was dilluted by methanol:water (4:1) and then fractionated by hexane (S Hex), methylene chloride (S_MTC), ethyl acetate (S_EA), a…
Breast cancer was commonly found in women in many countries. The crude incindence of breast cancer in Europe 109.8/100000 and the mortality rate around 28.4/100000. In lndonesia breast cancer is the most common cancer in women with the incidence 36.2/100000 and the mortality 18.6/100000. Early detection and adjuvant therapy has developed but the incidenee of relapse was still comm only found, …
Breast cancer may progress from an atypical lesion. Angiogenesis has an important role in the growth, invasion and metastasis of breast cancer, which can be reflected through the microvascular density (MVD). Tumor associated macrophages (TAMs) are stromal cells that can produce pro-angiogenic factor su ch as vascular endothelial growth factor (VEGF), and induce matrix metalloproteinase-9 (MMP-9…
Anemia merupakan faktor prognostik independen untuk pertahanan hidup pasien kanker. Penurunan kapasitas oksigen pada darah dapat menyebabkan terjadinya kondisi hipoksia pada jaringan kanker . Hipoksia pada jaringan kanker dapat mengaktivasi faktor transkripsi hypoxia-inducible factor-1α (HIF-1α) yang kemudian akan mentranskripsi banyak gen lain yang terlibat dalam invasi sel, angiogenesis, me…
Carcinogenesis process was a ffected by decrease in apoptotic activities marked by low Caspase- 3 expression. Soybean (Glycine max) tempe is a widely consumed permented food. Isoflavon content of tempe showed proapoptotic effect on cancer. The aim of this study is to know the effect of soybean tempe extract on Caspase -3 expression of C3H mice (Musmusculus) breast carcinogenesis model. This exp…