ABSTRACT Malaria is still one of the infectious disease that difficult to eradicate and become health problems all over the world including Indonesia. Half of the world's population are at risk of contracting malaria because of living in more than 100 countries still endemic to malaria. Malaria can be transmitted by Anopheles mosquitoes which vector of malaria. Indonesian government has carr…
ABSTRACT The settlement of Suku Anak Dalam in remote areas was malaria endemic and related with geographic condition, temperature, economics and social culture. This study carried out for 7 months in Pager Desa Village of Musi Ban yuasin District of South Sumatera Province as Suku Anak Dalam settlement. The aims of this study was to find out social cultural aspect regarding malaria and…
ABSTRACT BACKGROUND Hypertension is associated with endothelial-dependent vasodilation disorders, due to reduced nitric oxide (NO) availability and excessive angiotensin II (ANG¬II) activation. The objective of this study was to determine the association between matrix metallopeptidase 9 (MMP-9) gene polymorphism and hypertension in ethnic Javanese in the 40-80 year age group. METHODS…
ABSTRACT: BACKGROUND The prevalence of type-2 diabetes mellitus (T2DM) has been increasing rapidly in developed and developing countries. Many new loci associated with T2DM have been uncovered by genetic and genome- wide association studies, eg. the transcription factor 7-like 2 (TCF7L2) gene variant rs7895340 has been associated with type-2 diabetes mellitus. The aim of this …
ABSTRACT: BACKGROUND Type 2 diabetes mellitus is a heterogeneous disease which is characterized by variable degrees of insulin resistance and impaired insulin secretion. Uric acid has been identified as a marker for a number of metabolic and hemodynamic abnormalities. In diabetic patients, there is biochemical interaction between serum glucose and purine metabolism, with increased excret…
ABSTRACT: BACKGROUND Cervical cancer ranks second among female cancers worldwide and is widely associated with human papilloma vtrus (HPV) infection. However, HPV infection progression is influenced by various host factors. Epidermal growth factor (EGF) is a host factor important for proper epithelial proliferation and development, and may play a ro…
ABSTRACT BACKGROUND Diabetes mellitus (DM) is a group of metabolic diseases which are characterized by hyperglycemia, resulting in various complications. A major macrovascular complication of DM is cardiac failure due to cardiomyopathy. Hyperglycemia increases oxidative stress, so an oxidative-stress reducing therapeutic agent is required, e.g. the antioxidant quercetin. The aim of this study…
ABSTRACT: BACKGROUND Plant-derived herbal compounds have a long history of clinical use, better patient tolerance and acceptance. The are freely available natural compounds that can be safely used to prevent various ailments. Plants have been the basis of traditional medicine throughout the world for thousands of years and are providing mankind with new remedies. The objective of this st…
ABSTRACT An in vitro experimental research was conducted between October 2013 and January 2014. Neem lea were extracted in ethanol or hexane at various concentrations. A macrodilution test with 48-hour incubation time was done in triplicate on 8 groups of samples. These comprised the neem leaf ethanol extract (NLEE) at 0.5, 1.0, and 2.0 g/dL, neem leaf hexane extrac…
ABSTRACT An in vitro experimental research was conducted between October 2013 and January 2014. Neem lea were extracted in ethanol or hexane at various concentrations. A macrodilution test with 48-hour incubation time was done in triplicate on 8 groups of samples. These comprised the neem leaf ethanol extract (NLEE) at 0.5, 1.0, and 2.0 g/dL, neem leaf hexane extr…