Carcinogenesis process was a ffected by decrease in apoptotic activities marked by low Caspase- 3 expression. Soybean (Glycine max) tempe is a widely consumed permented food. Isoflavon content of tempe showed proapoptotic effect on cancer. The aim of this study is to know the effect of soybean tempe extract on Caspase -3 expression of C3H mice (Musmusculus) breast carcinogenesis model. This exp…
LR-2 is a compound analog of monastrol, an anticancer agent, which has been succesfully synthesised through the application of Biginelli reaction and one of LR compound series that synthesised in faculty of Farmacy, Universitas Gadjah Mada. This research was aimed to synthesized the LR-2 compound and to investigate the cytotoxicity of LR-2 on breast cncer cell line. The reaction was carried out…
Aim: to determine whether serum HER-2/neu level could be used as a prognostic factor in locally advanced breast cancer (LABC) and metastatic breast cancer (MBC). Methods: a prospective cohort study was done in LABC and MBC patients in dr. Sardjito Hospital Yogyakarta from April 2006 to March 2008. Serum concentration of HER-2/neu was measured by ELISA done before and after chemotherapy. HER-…
Background: As the world rates of breast cancer have increased, there has been a growing awareness of psychological effect of diagnosis and treatment and its role in the outcome of chronic disorders. Radiotherapy for breast cancer is an intense and cyclic treatment associated with number of side-effects. The sociodemographic factors of age, gender, marital status, education, immigrant status, i…