To Understand osteoporosis, we must comprehend the dynamics of bone mass acquisition and loss. Bone remodelling is an ongoing process in response to physical and metabolic influences on the skeleton. The biochemical processes of bone formation and bone loss and the various factors influencing them are presented.
During the progression stage, malignant tumors showed heterogenecity with some cells showing invasive and metastatic capabilities. Bone metastasis is usually hematogenic and predominantly in red bone marrow. This is supported by retrograde vein flow (Botson's plexus), micro-anatomy of the vascularized channels in red bone marrow in sinusoid system, high blood flow and higher concentration of cy…