Introduction: Pentagamayunon-0 (PG V-0) compound, a curcurnin analog, can inhibit steroido¬genesis of luteal cell culture by inhibiting the production ofprogesterone. The action site of PG V¬0 on steroidogenesis of luteal cells is still unknown. The objective of this study is to analyze the effect of PGV-0 on the Extracellular Signal Regulated Kinase (ERK) phosphorylation in steroido¬genesis…