Selective serotonin re-uptake inhibitors (SSRIs) have been considered to be promising drugs in psychiatric practice because of their selectivity to serotonin re-uptake transporter (SERT). Sertraline and fluoxetine are considered to be effective SSRIs as their ability in binding SERT and inhibit neurotransmitter recycling. However, they also bind norepinephrine and dopamine transporter (NAT and …