Muscle relaxants have two ways in their working. First, the muscle relaxant which worked in peripher (e.g.: dantrolen), and second, the muscle relaxant which worked in central (e.g.: diazepam, baclofen, carisoprodole, and Tizamidine). This article reviewed about tizanidine as muscle relaxant which worked centrally. This drugs especially worked in medulla spinalis. It was derived to imidazoline …