Controlled release dosage form is a dosage form with releases its contents in a controlled manner. Hydroxypropyl methylcellulose (HPMC) is a cellulose derivative which could from gel and substance may be used as matrix for a controlled release matrix dosage form. In this study, theophylline was used since this drug is suitable for controlled release dosage form and HPMC used was HPMC high visco…
The efficacy abd tolerability of
A study has been done on the theophylline serum levels and pulmonary function tests, comparising FVC, FEV1 and PEFR, on 21 patients with status asthmaticus, age 15 to 50 years, admitted in the Intensive Care Unit, Pulmonary Department Dr. Soetomo General Hospital Surabaya and treated with the standard protocol. Theophyllines serum levels and pulmonary functions test were measured immedistely af…
Controlled release dosage form is a dosage form with releases its contents in a controlled manner. Hydroxypropyl methylcellulose (HPMC) is a cellulose derivative which could from gel and substance may be used as matrix for a controlled release matrix dosage form. In this study, theophylline was used since this drug is suitable for controlled release dosage form and HPMC used was HPMC high visco…
Euphillin (R) retard (EN) is a slow-release preparation of theophylline marketed in Indonesia. The usual dose for patients with chronic bronchial asthma is 1 tablet twice daily. Information on the steady-state serum concentration of theophylline after ER administration is still lacking. This information is important because theophylline has a narrow margin of safety and a large inter-and intra-…