Multiple mini punch grafts is the placing of mini size of full thickness skins on to ulcer bedo They consist of epidermal and dermal component composed with hair follicles and other skin appendices where epidermal stem cells are located. The epidermal stem cells are the best source of epidermal cells in reconstruction of skin equivalent that is usually used for replacing classic split thickness…
Repeated ultraviolet B (UVB) irradiation on human skin has been considered to be responsible in premature aging process because UVB has been proved to inhibit collagen deposition and accelerates collagen degradation. Clinical studies because UVB has been proved to inhibit collagen deposition and accelerates collagen degradation in UVB irradiated normal human skin fibroblasts culture has not bee…
Ultraviolet A (UVA)irradiation on human skin can generate free radical and stimulate matrix metalloproteinase produktion resultingin collagen degradation and transforming growth factor beta (TGF-β) inhibition. It causes synthesis collagen inhibition and induces cell death. Α-Lipoic acid (ALA) is an universal antioxidant and a powerful scavenger of free radicals. In this study we investigated …
One of the factors that determine the success effficien wound healing is wound healing is wound healing rate, that can be achieved by increasing cell proliferation, angiogenesis or neovascularisation, and extracellular production . Dermal fibroblast is cell that plays an important role in wound healing. Fibroblast proliferation and neovascularisation are critical elements in granular tissue for…
UVB radiation may act as immunosuppressive agent through angerhans cels (LCS) depletion correlated with cyclobuthane pyrimidine dimer (CPD), as the most mutagenic photoproducts. Other studies showed that olive oil can prevent various human cancers which are defect of immune-surveillance. The effect of olive in the UVB-induced LCs depletion is still unclear. To discover the topical effect of ext…