Background: Obstructive sleep apnea has been known as one of risk factor for coronary artery disease (CAD). The aim ofthis study is to examine the relation of oxygen desaturation index (ODI) due to OSA and CAD. Methods: This study included 74 OSA men who were diagnosis of CAD by previous medical examination using treadmill and CT angiography and cardiac catheterization. Polysomnography was pe…
Nicotine is a major addictive compound in tobacco cigarette smoke. After being absorbed by the lung nicotine is rapidly metabolized and mainly inactivated to cotinine by hepatic cytochrome P450 2A6 (CYP2A6) enzyme. Genetic polymorphisrns in CYP2A6 may play a role in smoking behavior and nicotine dependence. CYP2A6* I A is the wild type of the CYP2A6 gene which is associated with normal or exten…