Primaquine decreased plasma concentration of ritonavir: single- and repeated-…

Background: The present study was aimed to explore the effects of ritonavir and primaquine combination given as a singledose or repeated-dose compared to ritonavir alone on ritonavir plasma concentration in the rats. Methods: In single-dose study, 30 male Spraque Dawley rats were randomly allocated to receive ritonavir 20 mg/kg BW or ritonavir 20 mg/kg BW + primaquine 1.2 mg/kg BW or ritonav…

A Meta-analysis on Treatment Effects of Thiazolidinediones for Type 2 Diabete…

Aim: to assess the effects of thiazolidinediones (pioglitazone and rosiglitazone) in the treatment of T2DM in Asian population. Methods: randomized controlled trials of T2DM patients in Asian population that compared pioglitazone or rosiglitazone with other treatments for more than 3 months and reported HbA1c data were included. Analyses for all outcomes were calculated using random effect m…

Primaquine decreased plasma concentration of ritonavir: single- and repeated-…

Background: The present study was aimed to explore the effects of ritonavir and primaquine combination given as a singledose or repeated-dose compared to ritonavir alone on ritonavir plasma concentration in the rats. Methods: In single-dose study, 30 male Spraque Dawley rats were randomly allocated to receive ritonavir 20 mg/kg BW or ritonavir 20 mg/kg BW + primaquine 1.2 mg/kg BW or ritonav…

Incretin-Based Therapies for Type 2 Diabetes in Asian Patients: Analysis of C…

Aim To review the efficacy and safety data on incretin-based therapies currently available (exenatide, liraglutide, sitagliptin, vildagliptin) for the treatment of type 2 diabetes mellitus in Asian population. Methods We conducted Medline search of all relevant randomized clinical trials of incretin-based therapies for type 2 diabetes mellitus in Asian populaticns. Data pertinent to the effica…

CYPA6 Gene Polymorphisms Impact to Nicotine Metabolism

Nicotine is a major addictive compound in tobacco cigarette smoke. After being absorbed by the lung nicotine is rapidly metabolized and mainly inactivated to cotinine by hepatic cytochrome P450 2A6 (CYP2A6) enzyme. Genetic polymorphisrns in CYP2A6 may play a role in smoking behavior and nicotine dependence. CYP2A6* I A is the wild type of the CYP2A6 gene which is associated with normal or exten…

Keamanan Penggunaan Antimikroba pada Kehamilan

Edisi

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ISBN/ISSN

0125-913X

Deskripsi Fisik

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Judul Seri

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No. Panggil

Cermin Dunia Kedokteran:37(1):12-16